Blood lead level (BLL) thresholds are essential for assessing lead exposure risks and guiding public health interventions. Key organizations, including the Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO), have established guidelines for BLLs 5 µg/dL as a critical threshold for assessing lead exposure and initiating further action. The CDC, through its Advisory Committee for Childhood Lead Poisoning Prevention (ACCLPP) and the Lead Exposure and Prevention Advisory Committee (LEPAC), regularly updates these thresholds based on emerging scientific evidence. Blood Lead Reference Value (BLRV) have evolved from 10 μg/dL (100 ppb) in 1991 to 5 μg/dL in 2012, and now revised to 3.5 μg/dL after identifying children with lead levels higher than 97.5% of U.S. children aged 1-5 years, emphasizing the
need for stringent regulations to protect at-risk populations. This update reflects a growing consensus that no safe level of lead exposure exists, particularly for children, who are more vulnerable to neurodevelopmental impairments even at lower levels (American Academy of Pediatrics Committee on Environmental Health. (2005), (Lanphear, B. P., et al. (2016).
